PAK4 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PAK4 in SW480 cell lysate with PAK4 polyclonal antibody (Cat # PAB12892) at 1 and 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PAK4 in human colon tissue with PAK4 polyclonal antibody (Cat # PAB12892) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAK4.
Immunogen
A synthetic peptide corresponding to 13 amino acids near internal region of human PAK4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PAK4 in SW480 cell lysate with PAK4 polyclonal antibody (Cat # PAB12892) at 1 and 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of PAK4 in human colon tissue with PAK4 polyclonal antibody (Cat # PAB12892) at 10 ug/mL . -
Gene Info — PAK4
Entrez GeneID
10298Protein Accession#
NP_005875Gene Name
PAK4
Gene Alias
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Gene Description
p21 protein (Cdc42/Rac)-activated kinase 4
Omim ID
605451Gene Ontology
HyperlinkGene Summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
p21(CDKN1A)-activated kinase 4|p21-activated kinase 4|protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
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Interactome
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Pathway
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Disease
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Publication Reference
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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
Cotteret S, Jaffer ZM, Beeser A, Chernoff J.
Molecular and Cellular Biology 2003 Aug; 23(16):5526.
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p21-activated kinases: three more join the Pak.
Jaffer ZM, Chernoff J.
The International Journal of Biochemistry & Cell Biology 2002 Jul; 34(7):713.
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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A.
The EMBO Journal 1998 Nov; 17(22):6527.
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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.
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