CARD10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CARD10 expression in EL4 cell lysate with CARD10 polyclonal antibody (Cat # PAB12878) at 5 and 10 ug /mL .
Immunocytochemistry
Immunocytochemistry of CARD10 in EL4 cells with CARD10 polyclonal antibody (Cat # PAB12878) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CARD10.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human CARD10.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CARD10 expression in EL4 cell lysate with CARD10 polyclonal antibody (Cat # PAB12878) at 5 and 10 ug /mL .Immunocytochemistry
Immunocytochemistry of CARD10 in EL4 cells with CARD10 polyclonal antibody (Cat # PAB12878) at 10 ug/mL . -
Gene Info — CARD10
Entrez GeneID
29775Protein Accession#
AAK26165Gene Name
CARD10
Gene Alias
BIMP1, CARMA3, MGC142219
Gene Description
caspase recruitment domain family, member 10
Omim ID
607209Gene Ontology
HyperlinkGene Summary
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM
Other Designations
Bcl10 binding protein and activator of NFKB|CARD-containing MAGUK 3 protein|caspase recruitment domain protein 10
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Interactome
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Disease
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Publication Reference
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Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator.
Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P.
The Journal of Biological Chemistry 2004 Aug; 279(33):34323.
Application：WB-Tr, Human, HEK 293 cells.
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New roles for Bcl10 in B-cell development and LPS response.
Fischer KD, Tedford K, Wirth T.
Trends in Immunology 2004 Mar; 25(3):113.
Application：IHC, WB, Human, Mouse, Mammalian cells.
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Protein modules as organizers of membrane structure.
Fanning AS, Anderson JM.
Current Opinion in Cell Biology 1999 Aug; 11(4):432.
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Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator.
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