CASP14 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CASP14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with CASP14 polyclonal antibody (Cat # PAB12873) at 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CASP14 in human liver tissue with CASP14 polyclonal antibody (Cat # PAB12873) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP14.
Immunogen
A synthetic peptide corresponding to C-terminus 16 amino acids of human CASP14.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CASP14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with CASP14 polyclonal antibody (Cat # PAB12873) at 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of CASP14 in human liver tissue with CASP14 polyclonal antibody (Cat # PAB12873) at 2.5 ug/mL . -
Gene Info — CASP14
Entrez GeneID
23581Protein Accession#
NP_033939Gene Name
CASP14
Gene Alias
MGC119078, MGC119079
Gene Description
caspase 14, apoptosis-related cysteine peptidase
Omim ID
605848Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq
Other Designations
apoptosis-related cysteine protease|caspase 14|caspase 14, apoptosis-related cysteine protease
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Interactome
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Disease
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Publication Reference
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Martinon F, Tschopp J.
Cell 2004 May; 117(5):561.
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Interleukin-18.
Gracie JA, Robertson SE, McInnes IB.
Journal of Leukocyte Biology 2003 Feb; 73(2):213.
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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA.
Science 1995 Mar; 267(5206):2000.
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Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
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