NRP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NRP1.
Immunogen
A synthetic peptide corresponding to C-terminus of human NRP1.
Host
Rabbit
Theoretical MW (kDa)
130
Reactivity
Bovine, Human
Specificity
This antibody recognizes ~130 KDa of human NRP1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
The 4 mg protein of whole tissue lysates derived from human brain were immunoprecipitated by 4 ug of NRP1 polyclonal antibody (Cat # PAB12718) o/n at 4°C, and probed by the same antibody at 1 : 1000. An immunoreactive band at ~130kDa was observed.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NRP1
Entrez GeneID
8829Gene Name
NRP1
Gene Alias
BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NP1, NRP, VEGF165R
Gene Description
neuropilin 1
Omim ID
602069Gene Ontology
HyperlinkGene Summary
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM
Other Designations
OTTHUMP00000020818|OTTHUMP00000020820|OTTHUMP00000020821|neuropilin-1|transmembrane receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity.
Glinka Y, Prud'homme GJ.
Journal of Leukocyte Biology 2008 Apr; 84(1):302.
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Molecular pathways regulating pro-migratory effects of Hedgehog signaling.
Hochman E, Castiel A, Jacob-Hirsch J, Amariglio N, Izraeli S.
The Journal of Biological Chemistry 2006 Nov; 281(45):33860.
Application:WB, Mouse, C166 cells.
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Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity.
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