DNM1L polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis with DNM1L polyclonal antibody (Cat # PAB12447) at 1 : 500x dilution. Lane 1 : DNM1L knockout. Lane 2 : DNM1L wildtype MEF.
Immunohistochemistry
Staining of DNM1L on human kidney cortex renal tubular epithelium and visceral epithelial cells of the glomerulus using DNM1L polyclonal antibody (Cat # PAB12447) at 2.5 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DNM1L.
Immunogen
A synthetic peptide corresponding to amino acids 500-600 of human DNM1L.
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Primates, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis with DNM1L polyclonal antibody (Cat # PAB12447) at 1 : 500x dilution. Lane 1 : DNM1L knockout. Lane 2 : DNM1L wildtype MEF.Immunohistochemistry
Staining of DNM1L on human kidney cortex renal tubular epithelium and visceral epithelial cells of the glomerulus using DNM1L polyclonal antibody (Cat # PAB12447) at 2.5 ug/mL. -
Gene Info — DNM1L
Entrez GeneID
10059Protein Accession#
O00429Gene Name
DNM1L
Gene Alias
DLP1, DRP1, DVLP, DYMPLE, DYNIV-11, FLJ41912, HDYNIV, VPS1
Gene Description
dynamin 1-like
Omim ID
603850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. [provided by RefSeq
Other Designations
Dnm1p/Vps1p-like protein|dynamin 1-like protein|dynamin family member proline-rich carboxyl-terminal domain less|dynamin-like protein 4|dynamin-like protein IV|dynamin-related protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle.
Niemann J, Johne C, Schröder S, Koch F, Ibrahim SM, Schultz J, Tiedge M, Baltrusch S.
Free Radical Biology & Medicine 2016 Nov; 102:174.
Application：WB, Mouse, Mouse hepatocytes.
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An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle.
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