NR1I2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NR1I2.
Immunogen
A synthetic peptide corresponding to human NR1I2.
Sequence
EQFAITLKSYIECNR
Host
Goat
Theoretical MW (kDa)
49.8, 53.9, 45.8
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
NR1I2 polyclonal antibody (Cat # PAB11612) (1 ug/mL) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NR1I2
Entrez GeneID
8856Protein Accession#
NP_003880.3;NP_071285.1;NP_148934.1Gene Name
NR1I2
Gene Alias
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Gene Description
nuclear receptor subfamily 1, group I, member 2
Omim ID
603065Gene Ontology
HyperlinkGene Summary
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq
Other Designations
orphan nuclear receptor PXR|steroid and xenobiotic receptor
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Interactome
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Disease
- Anemia
- Asthma
- Birth Weight
- Bone Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Cardiovascular Diseases
- Cholangitis
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Publication Reference
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A nuclear receptor-like pathway regulating multidrug resistance in fungi.
Thakur JK, Arthanari H, Yang F, Pan SJ, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley WS, Cormack BP, Wagner G, Naar AM.
Nature 2008 Apr; 452(7187):604.
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A nuclear receptor-like pathway regulating multidrug resistance in fungi.
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