NR1I2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human NR1I2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human NR1I2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human NR1I2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — NR1I2
Entrez GeneID
8856GeneBank Accession#
NR1I2Gene Name
NR1I2
Gene Alias
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Gene Description
nuclear receptor subfamily 1, group I, member 2
Omim ID
603065Gene Ontology
HyperlinkGene Summary
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq
Other Designations
orphan nuclear receptor PXR|steroid and xenobiotic receptor
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Interactome
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Disease
- Anemia
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