RPS6KB1 polyclonal antibody
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More Files
- More Functions
Immunoprecipitation
Western blot using RPS6KB1 polyclonal antibody (Cat # PAB10302) shows detection of a predominant band corresponding to RPS6KB1 in mouse brain extract (right lane) after immunoprecipitation.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RPS6KB1.
Immunogen
A synthetic peptide corresponding to C-terminus human RPS6KB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This affinity-purified antibody is directed against the human p70S6K protein.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:5000)
Western Blot (1:1000)
Immunoprecipitation (5 ug/mg protein sample)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM Tris-Cl, 500 mM NaCl, pH 8.0 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
Western blot using RPS6KB1 polyclonal antibody (Cat # PAB10302) shows detection of a predominant band corresponding to RPS6KB1 in mouse brain extract (right lane) after immunoprecipitation.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RPS6KB1
Entrez GeneID
6198Protein Accession#
P23443Gene Name
RPS6KB1
Gene Alias
PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha
Gene Description
ribosomal protein S6 kinase, 70kDa, polypeptide 1
Omim ID
608938Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
p70 S6 kinase, alpha 1|p70 S6 kinase, alpha 2|ribosomal protein S6 kinase, 70kD, polypeptide 1|serine/threonine kinase 14 alpha
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Interactome
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Pathway
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Disease
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