TRPV1 polyclonal antibody
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More Files
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Immunohistochemistry
Detection of TRPV1 in small neurons in rat dorsal root ganglion (DRG) using rabbit TRPV1 polyclonal antibody (Cat # PAB0698) at 1 : 2000 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRPV1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 608-621 human TRPV1.
Sequence
PSESTSHRWRGPA
Host
Rabbit
Reactivity
Human, Rat
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:1000-1:2000)
The optimal dilution should be determined by the end user.Storage Buffer
Lyophilized from whole serum.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 100 uL of sterile water, store at -20°C. Centrifuge to remove any insoluble material. Or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Detection of TRPV1 in small neurons in rat dorsal root ganglion (DRG) using rabbit TRPV1 polyclonal antibody (Cat # PAB0698) at 1 : 2000 dilution. -
Gene Info — TRPV1
Entrez GeneID
7442Protein Accession#
Q8NER1Gene Name
TRPV1
Gene Alias
DKFZp434K0220, VR1
Gene Description
transient receptor potential cation channel, subfamily V, member 1
Omim ID
602076Gene Ontology
HyperlinkGene Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq
Other Designations
capsaicin receptor|transient receptor potential vanilloid 1a|transient receptor potential vanilloid 1b|vanilloid receptor subtype 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Characterization of Functional TRPV1 Channels in the Sarcoplasmic Reticulum of Mouse Skeletal Muscle.
Lotteau S, Ducreux S, Romestaing C, Legrand C, Van Coppenolle F.
PLoS One 2013 Mar; 8(3):e58673.
Application：IF, Mouse, Single skeletal fibers.
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Characterization of Functional TRPV1 Channels in the Sarcoplasmic Reticulum of Mouse Skeletal Muscle.
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