TRPV1 polyclonal antibody
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More Files
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Immunohistochemistry
Immunohistochemical staining of rat spinal cord.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRPV1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 531-541 of human TRPV1.
Sequence
YFSHLKEYVAS
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Immunohistochemical analysis of rat DRG indicates a superb degree of specificity for this serum.
Form
Lyophilized
Purity
Whole serum
Recommend Usage
Immunohistochemistry (1:1000-1:2000)
The optimal dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS.
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with 100 uL of sterile water, store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Immunohistochemical staining of rat spinal cord. -
Gene Info — TRPV1
Entrez GeneID
7442Protein Accession#
Q8NER1Gene Name
TRPV1
Gene Alias
DKFZp434K0220, VR1
Gene Description
transient receptor potential cation channel, subfamily V, member 1
Omim ID
602076Gene Ontology
HyperlinkGene Summary
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq
Other Designations
capsaicin receptor|transient receptor potential vanilloid 1a|transient receptor potential vanilloid 1b|vanilloid receptor subtype 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Ketamine potentiates TRPV1 receptor signaling in the peripheral nociceptive pathways.
Flavia Lage Pessoa da Costa, Mauro Cunha Xavier Pinto, Duana Carvalho Dos Santos, Natália Virtude Carobin, Itamar Couto Guedes de Jesus, Luana Assis Ferreira, Silvia Guatimosim, Juliana Figueira da Silva, Célio José de Castro Junior.
Biochemical Pharmacology 2020 Sep; 182:114210.
Application：WB-Tr, Human, HEK 293 cells.
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Ketamine potentiates TRPV1 receptor signaling in the peripheral nociceptive pathways.
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