CCR10 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CCR10.
Immunogen
A synthetic peptide corresponding to amino acids 350-362 of human CCR10.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis for CCR10. Using CCR10 polyclonal antibody (Cat # PAB0165) at 2 ug/mL dilution against 10 ug of MCF-7 (a human breast cancer cell line) cell lysate.Immunohistochemistry (Frozen sections)
Flow Cytometry
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Gene Info — CCR10
Entrez GeneID
2826Gene Name
CCR10
Gene Alias
GPR2
Gene Description
chemokine (C-C motif) receptor 10
Omim ID
600240Gene Ontology
HyperlinkGene Summary
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM
Other Designations
CC chemokine receptor 10|G protein-coupled receptor 2
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Interactome
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Pathway
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Publication Reference
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In vitro and in vivo studies on CCR10 regulation by Annexin A1.
Rodrigues-Lisoni FC, Mehet DK, Peitl P Jr, John CD, da Silva Junior WA, Tajara E, Buckingham JC, Solito E.
FEBS Letters 2006 Jan; 580(5):1431.
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Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle.
Sell H, Dietze-Schroeder D, Kaiser U, Eckel J.
Endocrinology 2006 Jan; 147(5):2458.
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Identification of anti-inflammatory drugs according to their capacity to suppress type-1 and type-2 T cell profiles.
Moed H, Stoof TJ, Boorsma DM, von Blomberg BM, Gibbs S, Bruynzeel DP, Scheper RJ, Rustemeyer T.
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunolo 2004 Dec; 34(12):1868.
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Increased CCL27-CCR10 expression in allergic contact dermatitis: implications for local skin memory.
Moed H, Boorsma DM, Tensen CP, Flier J, Jonker MJ, Stoof TJ, von Blomberg BM, Bruynzeel DP, Scheper RJ, Rustemeyer T, Gibbs S.
The Journal of Pathology 2004 Aug; 204(1):39.
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Nickel-responding T cells are CD4+ CLA+ CD45RO+ and express chemokine receptors CXCR3, CCR4 and CCR10.
Moed H, Boorsma DM, Stoof TJ, von Blomberg BM, Bruynzeel DP, Scheper RJ, Gibbs S, Rustemeyer T.
The British Journal of Dermatology 2004 Jun; 151(1):32.
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Expression of the T-helper 2-specific chemokine receptor CCR4 on CCR10-positive lymphocytes in atopic dermatitis skin but not in psoriasis skin.
C Vestergaard, M Deleuran, B Gesser, C Gronhoj Larsen.
The British Journal of Dermatology 2003 Sep; 149(3):457.
Application:IHC-Fr, Human, Human skin biopsies.
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In vitro and in vivo studies on CCR10 regulation by Annexin A1.
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