CD244 (Human) Recombinant Protein
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More Files
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Enzyme-linked Immunoabsorbent Assay
Immobilized Human CD48, His Tag at 1 ug/mL (100 uL/well) on the plate. Dose response curve for Human 2B4, hFc Tag with the EC50 of 0.45 ug/mL determined by ELISA.
SEC-HPLC
The purity of Human 2B4/CD244/SLAMF4 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human 2B4/CD244/SLAMF4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human CD244 (Q9BZW8-2, Cys22-Arg221) partial recombinant protein with hFc tag at C-Terminus expressed in HEK293 cells.
Sequence
Cys22-Arg221
Host
Human
Theoretical MW (kDa)
49
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human 2B4/CD244/SLAMF4 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human 2B4/CD244/SLAMF4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human CD48, His Tag at 1 ug/mL (100 uL/well) on the plate. Dose response curve for Human 2B4, hFc Tag with the EC50 of 0.45 ug/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — CD244
Entrez GeneID
51744Protein Accession#
Q9BZW8-2Gene Name
CD244
Gene Alias
2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Gene Description
CD244 molecule, natural killer cell receptor 2B4
Omim ID
605554Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells express both activating and inhibitory cell surface receptors. Inhibitory signaling receptors all possess cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, or ITIMs, whereas the activating receptors lack ITIMs and associate with DAP12 (TYROBP; MIM 604142), which contains an immunoreceptor tyrosine-based activation motif, or ITAM. Killer cell immunoglobulin (Ig)-like receptors, or KIRs (see KIR2DL1; MIM 604936), and other NK cell receptors interact with major histocompatibility complex (MHC) molecules (see MIM 142800). Members of the CD2 (MIM 186990) family adhere to each other instead. The cell surface glycoprotein 2B4 is related to CD2 and is implicated in the regulation of NK- and T-cell function (Boles et al., 1999 [PubMed 10458320]).[supplied by OMIM
Other Designations
CD244 natural killer cell receptor 2B4|NK cell activation inducing ligand NAIL|OTTHUMP00000027884|natural killer cell receptor 2B4
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Interactome
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Pathway
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Disease
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