TNFSF14 (Human) Recombinant Protein
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More Files
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Enzyme-linked Immunoabsorbent Assay
Immobilized Human HVEM, His Tag at 1 ug/mL (100 uL/Well) on the plate. Dose response curve for Human LIGHT, hFc Tag with the EC50 of 14.2 ng/mL determined by ELISA.
SEC-HPLC
The purity of Human LIGHT is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human LIGHT on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human TNFSF14 (O43557-1, Asp74-Val240) partial recombinant protein with hFc tag at N-Terminus expressed in HEK293 cells.
Sequence
Asp74-Val240
Host
Human
Theoretical MW (kDa)
45.5
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human LIGHT is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human LIGHT on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human HVEM, His Tag at 1 ug/mL (100 uL/Well) on the plate. Dose response curve for Human LIGHT, hFc Tag with the EC50 of 14.2 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — TNFSF14
Entrez GeneID
8740Protein Accession#
O43557-1Gene Name
TNFSF14
Gene Alias
CD258, HVEML, LIGHT, LTg, TR2
Gene Description
tumor necrosis factor (ligand) superfamily, member 14
Omim ID
604520Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
delta transmembrane LIGHT|herpesvirus entry mediator A|ligand for herpesvirus entry mediator|tumor necrosis factor ligand superfamily, member 14|tumor necrosis factor receptor-like 2|tumor necrosis factor superfamily member LIGHT
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Interactome
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Pathway
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Disease
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