FCGRT/B2M (Human) Recombinant Protein
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More Files
- More Functions
Enzyme-linked Immunoabsorbent Assay
Immobilized Human FcRn, His Tag at 1 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-FcRn Antibody, hFc Tag with the EC50 of 12.4 ng/mL determined by ELISA (QC Test).
Surface Plasmon Resonance
Human FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind Human IgG1 Fc, No Tag with an affinity constant of 0.28 uM as determined in SPR assay (Biacore T200).
SEC-HPLC
The purity of Human FcRn is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human FcRn on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human FCGRT | B2M (P55899-1 | P61769-1, Ala24-Ser297 | Ile21-Met119) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Ala24-Ser297 | Ile21-Met119
Host
Human
Theoretical MW (kDa)
31.5
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human FcRn is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human FcRn on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SPR
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human FcRn, His Tag at 1 ug/mL (100 uL/well) on the plate. Dose response curve for Anti-FcRn Antibody, hFc Tag with the EC50 of 12.4 ng/mL determined by ELISA (QC Test).Functional Study
SDS-PAGE
Surface Plasmon Resonance
Human FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind Human IgG1 Fc, No Tag with an affinity constant of 0.28 uM as determined in SPR assay (Biacore T200). -
Gene Info — B2M
Entrez GeneID
567Protein Accession#
P55899-1(FCGRT) | P61769-1(B2M)Gene Name
B2M
Gene Alias
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Gene Description
beta-2-microglobulin
Gene Ontology
HyperlinkGene Summary
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia
Other Designations
beta chain of MHC class I molecules|beta-2-microglobin
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Gene Info — FCGRT
Entrez GeneID
2217Protein Accession#
P55899-1(FCGRT) | P61769-1(B2M)Gene Name
FCGRT
Gene Alias
FCRN, alpha-chain
Gene Description
Fc fragment of IgG, receptor, transporter, alpha
Omim ID
601437Gene Ontology
HyperlinkGene Summary
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
FcRn alpha chain|IgG Gc receptor|neonatal Fc-receptor
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Interactome
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Pathway
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Disease
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