CDH3 (Human) Recombinant Protein
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Specification
Product Description
Human CDH3 (P22223-1, Asp108-Gly654) partial recombinant protein with His tag at C-Terminus expressed in HEK293 cells.
Sequence
Asp108-Gly654
Host
Human
Theoretical MW (kDa)
64.31999999999999
Form
Liquid
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human CDH3 is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human CDH3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at -80°C for 12 Month.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Anti-CDH3 Antibody, hFc Tag at 2 ug/mL (100 uL/Well) on the plate. Dose response curve for Human CDH3, His Tag with the EC50 of 2.1 ug/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — CDH3
Entrez GeneID
1001Protein Accession#
P22223-1Gene Name
CDH3
Gene Alias
CDHP, HJMD, PCAD
Gene Description
cadherin 3, type 1, P-cadherin (placental)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq
Other Designations
cadherin 3, type 1|calcium-dependent adhesion protein, placental
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Interactome
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Pathway
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Disease
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