IL22RA1/IL10RB (Human) Recombinant Protein
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Specification
Product Description
Human IL22RA1 | IL10RB (Q8N6P7|Q08334, His16-Thr228 | Met20-Ser220) partial recombinant protein with hFc-Avi tag at C-terminus expressed in HEK293 cells.
Sequence
His16-Thr228 | Met20-Ser220
Host
Human
Theoretical MW (kDa)
52.07
Form
Liquid
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human IL-22R alpha 1&IL-10R beta is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human IL-22R alpha 1&IL-10R beta on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS pH 7.4 (8% trehalose)
Storage Instruction
Store at -80°C for 12 Month.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human IL-22, His Tag at 2 ug/mL (100 uL/well) on the plate. Dose response curve for Human IL-22R alpha 1 & IL-10R beta, hFc Tag with the EC50 of 0.42 ug/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — IL10RB
Entrez GeneID
3588Protein Accession#
Q8N6P7(IL-22R alpha 1) | Q08334(IL-10R beta)Gene Name
IL10RB
Gene Alias
CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
Gene Description
interleukin 10 receptor, beta
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq
Other Designations
cytokine receptor class-II CRF2-4|cytokine receptor family II, member 4
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Gene Info — IL22RA1
Entrez GeneID
58985Protein Accession#
Q8N6P7(IL-22R alpha 1) | Q08334(IL-10R beta)Gene Name
IL22RA1
Gene Alias
CRF2-9, IL22R, IL22R1
Gene Description
interleukin 22 receptor, alpha 1
Omim ID
605457Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq
Other Designations
OTTHUMP00000003073
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Interactome
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Pathway
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Disease
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