TNFSF9 (Human) Recombinant Protein
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Specification
Product Description
Human TNFSF9 recombinant protein expressed in Escherichia coli.
Sequence
REGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLPSPRSE
Host
Escherichia coli
Theoretical MW (kDa)
19.5
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
chromatographic
Purity
> 97% as determined by (a) RP-HPLC.(b) SDS-PAGE.
Activity
ED50 is 5-10 ng/mL, measured by the dose-dependent stimulation of IL-8 production by human PBMC a chemotaxis bioassay using human MCF-7 cells, corresponding to a specific activity of 1.0 x 105-2.0 x 105 IU/mg.
Storage Buffer
Lyophilized from a solution containing 1X PBS, pH 7.4. Reconstitute the lyophilized powder in ddH2O to 100 ug/mL.
Storage Instruction
Lyophilized protein at room temperature for 3 weeks, should be stored at -20°C. Protein aliquots at 4°C for 2-7 days and should be stored at -20°C to -80°C for long term storage.
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — TNFSF9
Entrez GeneID
8744Protein Accession#
P41273Gene Name
TNFSF9
Gene Alias
4-1BB-L, CD137L
Gene Description
tumor necrosis factor (ligand) superfamily, member 9
Omim ID
606182Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction
Other Designations
homolog of mouse 4-1BB-L|receptor 4-1BB ligand
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