TNFRSF11A (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF11A recombinant protein expressed in Escherichia coli.
Sequence
QIAPPCTSEKHYEHLGRCCNKCEPGKYMSSKCTTTSDSVCLPCGPDEYLDSWNEEDKCLLHKVCDTGKALVAVVAGNSTTPRRCACTAGYHWSQDCECCRRNTECAPGLGAQHPLQLNKDTVCKPCLAGYFSDAFSSTDKCRPWTNCTFLGKRVEHHGTEKSDAVCSSSLPARK
Host
Escherichia coli
Theoretical MW (kDa)
19.1
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
chromatographic
Purity
> 98% as determined by (a) RP-HPLC.(b) SDS-PAGE.
Activity
ED50 < 50 ng/mL, measured by the ability to inhibit sRANK Ligand induced nuclear factor kappa B (NFkappaB) in RAW 264.7 cells, corresponding to a specific activity of > 2.0 x 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Isotype
Escherichia Coli.
Storage Buffer
Lyophilized from a solution containing 20 mM Tris-HCl, pH 8.0, 150 mM NaCl. Reconstitute the lyophilized powder in ddH2O to 100 ug/mL.
Storage Instruction
Lyophilized protein at room temperature for 3 weeks, should be stored at -20°C. Protein aliquots at 4°C for 2-7 days and should be stored at -20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — TNFRSF11A
Entrez GeneID
8792Protein Accession#
Q9Y6Q6Gene Name
TNFRSF11A
Gene Alias
CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
Gene Description
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq
Other Designations
loss of heterozygosity, 18, chromosomal region 1|osteoclast differentiation factor receptor|receptor activator of nuclear factor-kappa B|tumor necrosis factor receptor superfamily, member 11a|tumor necrosis factor receptor superfamily, member 11a, activat
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Interactome
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