INS (Human) Recombinant protein
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Specification
Product Description
Human INS (P01308, 25 a.a. - 110 a.a) partial recombinant protein with His tag at N-terminal expressed in Escherichia Coli.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSFVNQHLC GSHLVEALYL VCGERGFFYT PKTRREAEDL QVGQVELGGG PGAGSLQPLA LEGSLQKRGI VEQCCTSICS LYQLENYCN
Host
Escherichia coli
Theoretical MW (kDa)
11.8
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 95% by SDS-PAGE.
Activity
Measured in a cell proliferation assay using MCF7 human breast cancer cell. The ED50 for this effect is less or equal to 4 ug/mL.
Storage Buffer
In PBS, pH 7.4 and 10% glycerol
Storage Instruction
Store at 4°C for 2~4 week. For long term storage store at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — INS
Entrez GeneID
3630Protein Accession#
P01308Gene Name
INS
Gene Alias
ILPR, IRDN
Gene Description
insulin
Gene Ontology
HyperlinkGene Summary
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq
Other Designations
OTTHUMP00000011161|OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
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