BMP4 (Human) Recombinant Protein
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Specification
Product Description
Human BMP4 (P12644) recombinant protein expressed in CHO cells.
Sequence
SPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR.
Host
Human
Theoretical MW (kDa)
26.2
Form
Lyophilized
Preparation Method
CHO cell expression system
Purity
> 95% by SDS-PAGE
Activity
The ED50 as calculated by Alkaline phosphatase activity induced in ATDC-5 cells is 15ng/mL corresponding to a specific activity which is 6.7 x 104 units/mg.
Storage Buffer
The protein was lyophilized from a sterile (0.2um) filtered solution containing 0.1% Trifluoroacetic Acid (TFA).
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
Functional Study
SDS-PAGE
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Gene Info — BMP4
Entrez GeneID
652Protein Accession#
P12644Gene Name
BMP4
Gene Alias
BMP2B, BMP2B1, MCOPS6, ZYME
Gene Description
bone morphogenetic protein 4
Omim ID
112262Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq
Other Designations
bone morphogenetic protein 2B
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Interactome
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Pathway
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Disease
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