BDNF (Human) Recombinant Protein,homodimer
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Specification
Product Description
Human BDNF (P23560) recombinant protein expressed in Escherichia coli.
Sequence
MHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR.
Host
Escherichia coli
Theoretical MW (kDa)
27
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 97% by HPLC and SDS PAGE
Activity
The ED50 as determined by the dose-dependent induction of C6 cells proliferation, is 1.3-2ug/mL.
Storage Buffer
Lyophilized without additives.
Storage Instruction
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles. -
Applications
Functional Study
SDS-PAGE
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Gene Info — BDNF
Entrez GeneID
627Protein Accession#
P23560Gene Name
BDNF
Gene Alias
MGC34632
Gene Description
brain-derived neurotrophic factor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
Other Designations
neurotrophin
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Interactome
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Pathway
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Disease
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