AREG (Human) Recombinant Protein
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Specification
Product Description
Human AREG (P15514) recombinant protein expressed in Escherichia coli.
Sequence
SVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSK.
Host
Escherichia coli
Theoretical MW (kDa)
11.3
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 95% by HPLC and SDS PAGE
Activity
Determined by the ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/mL, corresponding to a specific activity of 100,000-200,000 units/mg.
Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles. -
Applications
Functional Study
SDS-PAGE
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Gene Info — AREG
Entrez GeneID
374Protein Accession#
P15514Gene Name
AREG
Gene Alias
AR, CRDGF, MGC13647, SDGF
Gene Description
amphiregulin
Omim ID
104640Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq
Other Designations
OTTHUMP00000160473|colorectum cell-derived growth factor|schwannoma-derived growth factor
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