IL15RA (Human) Recombinant Protein
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Specification
Product Description
Human IL15RA (Q13261, 31 a.a. - 205 a.a.) partial recombinant protein with hlgG-His tag at C-terminus expressed in Sf9 cells.
Sequence
ADPITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
Host
insect
Theoretical MW (kDa)
45.6
Form
Liquid
Preparation Method
Sf9 cell expression system
Purity
> 90% by SDS-PAGE
Activity
ED50 is < 2 ng/mL with Human IL-15 as determined by the ability to inhibit proliferation using CTLL2 mouse cytotoxic T cells
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS pH 7.4 (10% glycerol)
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IL15RA
Entrez GeneID
3601Protein Accession#
Q13261Gene Name
IL15RA
Gene Alias
MGC104179
Gene Description
interleukin 15 receptor, alpha
Omim ID
601070Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine receptor that specifically binds IL15 with high affinity. The receptors of IL15 and IL2 share two subunits, the IL2R beta and IL2R gamma chains. This forms the basis of many overlapping biological activities of IL15 and IL2. The IL2 receptor requires an additional IL2-specific alpha subunit for high affinity IL2 binding. This protein is structurally related to IL2R alpha, but is capable of binding IL15 with high affinity independent of other subunits, which suggests the distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported. The full length sequences of only two variants encoding distinct isoforms are available. [provided by RefSeq
Other Designations
OTTHUMP00000019021|OTTHUMP00000019022
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Interactome
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Disease
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