TNFRSF17 (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF17 (Q02223, 5 a.a. - 54 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
AGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA
Host
Escherichia coli
Theoretical MW (kDa)
5.4
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 98% by SDS-PAGE
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The ED50 was determined by the ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is < 40 ng/ml, corresponding to a specific activity of > 2.5 x 104 IU/mg in the presence of 100.0 ng/ml human APRIL.
Storage Buffer
Lyophilized from sterile distilled Water up to 0.1 - 1.0 mg/ml
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — TNFRSF17
Entrez GeneID
608Protein Accession#
Q02223Gene Name
TNFRSF17
Gene Alias
BCM, BCMA, CD269
Gene Description
tumor necrosis factor receptor superfamily, member 17
Omim ID
109545Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq
Other Designations
B cell maturation antigen|B-cell maturation factor|OTTHUMP00000160261
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