CCL7 (Human) Recombinant Protein
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Lane 1: non-reducing conditions
Lane 2: reducing conditions
Result of activity analysis
Result of activity analysis
Human THP-1 cells were allowed to migrate to human CCL7 at (0, 0.1, 1, 10, 100 and 1000 ng/mL). After 45 minutes, cells that migrated were counted using a luminescent substrate and displayed on the bar graph above.
-
Specification
Product Description
Human CCL7 (Q7Z7Q8) recombinant protein expressed in Escherichia coli.
Sequence
QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL
Host
Escherichia coli
Theoretical MW (kDa)
9
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the ability of MCP-3 to chemoattract THP-1 cells and is detectable starting at 10 ng/mL.
Quality Control Testing
1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue
Lane 1: non-reducing conditions
Lane 2: reducing conditionsStorage Buffer
No additive
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
-
Applications
Functional Study
SDS-PAGE
-
Gene Info — CCL7
Entrez GeneID
6354Protein Accession#
Q7Z7Q8Gene Name
CCL7
Gene Alias
FIC, MARC, MCP-3, MCP3, MGC138463, MGC138465, NC28, SCYA6, SCYA7
Gene Description
chemokine (C-C motif) ligand 7
Omim ID
158106Gene Ontology
HyperlinkGene Summary
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq
Other Designations
monocyte chemoattractant protein 3|monocyte chemotactic protein 3|small inducible cytokine A7 (monocyte chemotactic protein 3)
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation.
Wei Jiang, Fan Zhu, Huiming Xu, Li Xu, Haoyang Li, Xin Yang, Shabbir Khan Afridi, Shuiqing Lai, Xiusheng Qiu, Chunxin Liu, Huilu Li, Youming Long, Yuge Wang, Kevin Connolly, Jack A Elias, Chun Geun Lee, Yaxiong Cui, Yu-Wen Alvin Huang , Wei Qiu, Changyong Tang.
Science Advances 2023 Sep; 9(39):eadg8148.
Application：Cell Culture, Mouse, Mouse neural stem cells.
-
CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com