CCL18 (Human) Recombinant Protein
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Specification
Product Description
Human CCL18 (P55774, 21 a.a. - 89 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
AQVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLKLNA
Host
Escherichia coli
Theoretical MW (kDa)
8
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
Ion exchange column and HPLC reverse phase column
Purity
> 90% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng/ug (1 EU/ug)
Activity
Determined by the ability to chemoattract human T cells using a concentration range of 2.0-40.0 ng/mL.
Storage Buffer
Lyophilized from 20 mM PB, 100 mM NaCl, pH 7.5
Storage Instruction
Store at -20°C on dry atmosphere for 2 years.
After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — CCL18
Entrez GeneID
6362Protein Accession#
P55774Gene Name
CCL18
Gene Alias
AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18
Gene Description
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
Omim ID
603757Gene Ontology
HyperlinkGene Summary
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq
Other Designations
CC chemokine ligand 18|alternative macrophage activation-associated CC chemokine 1|chemokine (C-C), dendritic|dendritic cell chemokine 1|macrophage inflammatory protein 4|pulmonary and activation-regulated chemokine|small inducible cytokine A18|small indu
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Interactome
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Pathway
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Disease
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Publication Reference
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CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway.
Qin Y, Wang J, Zhu G, Li G, Tan H, Chen C, Pi L, She L, Chen X, Wei M, Li Z, Liu Z, Huang D, Liu Y, Zhang X.
Journal of Cellular and Molecular Medicine 2019 Apr; 23(4):2689.
Application：Func, Human, Tu686, 6-10B cells.
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Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck.
She L, Qin Y, Wang J, Liu C, Zhu G, Li G, Wei M, Chen C, Liu G, Zhang D, Chen X, Wang Y, Qiu Y, Tian Y, Zhang X, Liu Y, Huang D.
Cancer Cell International 2018 Aug; 18:120.
Application：Func, Human, FaDu, Tu686 cells.
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CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway.
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