FKBP6 (Human) Recombinant Protein
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Specification
Product Description
Human FKBP6 (NP_003593, 1 a.a. - 327 a.a.) full-length recombinant protein with His tag expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES
Host
Escherichia coli
Theoretical MW (kDa)
39.3
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
Conventional Chromatography
Concentration
0.5 mg/mL
Purity
> 95% by SDS-PAGE
Activity
Specific activity is > 190 nmoles/min/ug, and is defined as the amount of enzyme that cleaves 1 umole of suc-AAFP-pNA per minute at 25°C in Tris-HCl pH 8.0 using chymotrypsin.
Quality Control Testing
Loading 3 ug protein in 15% SDS-PAGE
Storage Buffer
In 20 mM Tris-HCl buffer, 50 mM NaCl, 1 mM EDTA, pH 8.0 (1 mM DTT, 40% glycerol).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — FKBP6
Entrez GeneID
8468Protein Accession#
NP_003593Gene Name
FKBP6
Gene Alias
FKBP36, MGC87179, PPIase
Gene Description
FK506 binding protein 6, 36kDa
Omim ID
604839Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds to clathrin heavy chain and heat shock protein 72. This gene is found to be deleted in Williams syndrome, and the orthologous gene in mouse is essential for fertility and homologous pairing in male meiosis. [provided by RefSeq
Other Designations
FK506 binding protein 6|FK506 binding protein 6 (36kD)|FK506-binding protein 6 (36kD)|immunophilin FKBP36|peptidylprolyl cis-trans isomerase|rotamase
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Interactome
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Disease
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