COBRA1 monoclonal antibody, clone F7E4
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More Files
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Western Blot (Tissue lysate)
Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 62K COBRA1 protein.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant COBRA1.
Immunogen
Recombinant protein corresponding to full length human COBRA1.
Host
Mouse
Theoretical MW (kDa)
62
Reactivity
Human, Mouse, Rat
Specificity
This antibody has been directly tested for reactivity in Western blots with human, mouse and rat tissue. specific to the ~62k COBRA1 protein in Western blots of neonatal rat brain lysate.
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 62K COBRA1 protein. -
Gene Info — COBRA1
Entrez GeneID
25920Protein Accession#
Q8WX92Gene Name
COBRA1
Gene Alias
DKFZp586B0519, KIAA1182, NELF-B, NELFB
Gene Description
cofactor of BRCA1
Gene Ontology
HyperlinkGene Summary
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM
Other Designations
negative elongation factor protein B
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Interactome
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Publication Reference
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COBRA1 inhibits AP-1 transcriptional activity in transfected cells.
Zhong H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Q.
Biochemical and Biophysical Research Communications 2004 Dec; 325(2):568.
Application：WB-Tr, Human, MCF-7 cells.
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Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.
Aiyar SE, Sun JL, Blair AL, Moskaluk CA, Lu YZ, Ye QN, Yamaguchi Y, Mukherjee A, Ren DM, Handa H, Li R.
Genes & Development 2004 Sep; 18(17):2134.
Application：ChIP, IHC-P, WB, Human, Human mammary gland, MCF-7, T47D cells.
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COBRA1 inhibits AP-1 transcriptional activity in transfected cells.
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