SLC17A7 monoclonal antibody, clone McKA1
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of SLC17A7.
Immunogen
A synthetic peptide corresponding to human SLC17A7.
Sequence
CGATHSTFQPPRPPPPVRDY
Host
Mouse
Reactivity
Human, Rat
Specificity
This antibody reveals the presence of the 58 KDa VGlut 1 protein on western blot of extract of homogenized cerebral cortex cells. It shows very neat reaction with VGlut1 epitope of human midfrontal gyrus brain tissue in immunohistochemical labelings.
Form
Lyophilized
Isotype
IgG2a
Recommend Usage
Immunocytochemistry (1:5000)
Immunohistochemistry (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C or -20°C on dry atmosphere.
After reconstitution with water and glycerol (1:1), store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SLC17A7
Entrez GeneID
57030Protein Accession#
Q9P2U7Gene Name
SLC17A7
Gene Alias
BNPI, VGLUT1
Gene Description
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Omim ID
605208Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq
Other Designations
brain-specific Na-dependent inorganic phosphate cotransporter|solute carrier family 17, member 7|vesicular glutamate transporter 1
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Interactome
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Disease
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Publication Reference
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The amyloid pathology progresses in a neurotransmitter-specific manner.
Bell KF, Ducatenzeiler A, Ribeiro-da-Silva A, Duff K, Bennett DA, Cuello AC.
Neurobiology of Aging 2006 Nov; 27(11):1644.
Application：IHC, WB-Ti, Human, Rat, Brain.
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The amyloid pathology progresses in a neurotransmitter-specific manner.
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