THBD monoclonal antibody, clone QBEND/40
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Specification
Product Description
Mouse monoclonal antibody raised against THBD.
Immunogen
Human THBD.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes all human endothelium tested. Preliminary evidence suggests that this antibody recognizes Thrombomodulin, but does not inhibit Thrombomodulin dependent activation of protein C.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Flow Cytometry (10ul of the suggested working dilution (neat) to label 106 cells in 100ul)
Immunohistochemistry (Frozen sections) (1:10-1:100)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — THBD
Entrez GeneID
7056Gene Name
THBD
Gene Alias
CD141, THRM, TM
Gene Description
thrombomodulin
Omim ID
188040Gene Ontology
HyperlinkGene Summary
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq
Other Designations
CD141 antigen|OTTHUMP00000030415|fetomodulin
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