PECAM1 monoclonal antibody, clone MEM-05 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native PECAM1.
Immunogen
Native purified PECAM1 from leukocytes of patient suffering from LGL-type leukaemia.
Host
Mouse
Theoretical MW (kDa)
130-140
Reactivity
Human
Specificity
This antibody reacts with CD31 (PECAM-1), a 130-140 KDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stem cells of the myeloid lineage.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — PECAM1
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Interactome
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Pathway
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Disease
- Acute Disease
- Angina Pectoris
- Arteriosclerosis
- Asthma
- Astrocytoma
- Atherosclerosis
- Brain Ischemia
- Bronchiolitis
- Cadaver
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Publication Reference
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PECAM-1-regulated signalling thresholds control tolerance in anergic transgenic B-cells.
Wong MX, Hayball JD, Jackson DE.
Molecular Immunology 2007 Oct; 45(6):1767.
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PECAM-1: a multi-functional molecule in inflammation and vascular biology.
Woodfin A, Voisin MB, Nourshargh S.
Arteriosclerosis, Thrombosis, and Vascular Biology 2007 Sep; 27(12):2514.
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Induction of hyporesponsiveness and impaired T lymphocyte activation by the CD31 receptor:ligand pathway in T cells.
Prager E, Staffler G, Majdic O, Saemann M, Godar S, Zlabinger G, Stockinger H.
Journal of Immunology (Baltimore, Md. : 1950) 2001 Feb; 166(4):2364.
Application:Flow Cyt, Human, Human T cell clones EP 27.1 and O A.1.
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PECAM-1-regulated signalling thresholds control tolerance in anergic transgenic B-cells.
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