RARA monoclonal antibody, clone 763
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of RARA.
Immunogen
A synthetic peptide corresponding to N-terminus human RARA.
Host
Mouse
Theoretical MW (kDa)
48
Reactivity
Bovine, Dog, Human, Mouse
Specificity
Specific for the ~48k RARB isotype.
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RARA protein. Using RARA monoclonal antibody, clone 763 (Cat # MAB1779). -
Gene Info — RARA
Entrez GeneID
5914Protein Accession#
P10276Gene Name
RARA
Gene Alias
NR1B1, RAR
Gene Description
retinoic acid receptor, alpha
Omim ID
180240Gene Ontology
HyperlinkGene Summary
Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM
Other Designations
OTTHUMP00000164454|OTTHUMP00000164456|Retinoic acid receptor, alpha polypeptide|nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
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Interactome
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Pathway
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Disease
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Publication Reference
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Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.
Joshi S, Guleria R, Pan J, DiPette D, Singh US.
Oncogene 2006 Jan; 25(2):240.
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Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer.
Abu J, Batuwangala M, Herbert K, Symonds P.
The Lancet. Oncology 2005 Sep; 6(9):712.
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Role of retinoid signalling in the adult brain.
Lane MA, Bailey SJ.
Progress in Neurobiology 2005 Mar; 75(4):275.
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Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells.
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