CD160 monoclonal antibody, clone BY55
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Flow Cytometry
Flow cytometric analysis (surface staining) of human peripheral blood cells with anti-CD160 PE.
-
Specification
Product Description
Mouse monoclonal antibody raised against human CD160.
Immunogen
Human NK cell line YT2C2.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. It detects both GPI-anchored and transmembrane form of CD160.
Form
Liquid
Purification
Precipitation method and chromatography
Isotype
IgM
Recommend Usage
Flow Cytometry
Immunoprecipitation
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 8.0 (15 mM sodium azide).
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Flow Cytometry
Flow cytometric analysis (surface staining) of human peripheral blood cells with anti-CD160 PE. -
Gene Info — CD160
Entrez GeneID
11126Gene Name
CD160
Gene Alias
BY55, FLJ46513, NK1, NK28
Gene Description
CD160 molecule
Omim ID
604463Gene Ontology
HyperlinkGene Summary
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq
Other Designations
CD160 antigen|OTTHUMP00000015585|natural killer cell receptor, immunoglobulin superfamily member
-
Interactome
-
Publication Reference
-
Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.
Jerome Giustiniani, Armand Bensussan, and Anne Marie-Cardine.
Journal of Immunology 2009 Jan; 182(1):63.
Application：Flow Cyt, Func, IP, WB-Tr, Human, NK cell line NK92, Jurkat cells.
-
BY55/CD160 cannot be considered a cytotoxic marker in cytomegalovirus-specific human CD8(+) T cells.
Merino J, Ramírez N, Moreno C, Toledo E, Fernández M, Sánchez-Ibarrola A.
Clinical and Experimental Immunology 2007 Jul; 149(1):87.
Application：Flow Cyt, Human, Human lymphocytes.
-
Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com