NPHS1 monoclonal antibody, clone Y17-R
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of recombinanr NPHS1 protein with NPHS1 monoclonal antibody, clone Y17-R (Cat # MAB1638).
Lane 1: 50 ng. Lane 2: 100 ng. Lane 3: 200 ng.
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of NPHS1.
Immunogen
A synthetic peptide corresponding to fifth Ig-like domain (between residues Cys465-Cys528) of human NPHS1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:5000)
ELISA (1:500001:100000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, pH 8.0 (10 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of recombinanr NPHS1 protein with NPHS1 monoclonal antibody, clone Y17-R (Cat # MAB1638).
Lane 1: 50 ng. Lane 2: 100 ng. Lane 3: 200 ng.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NPHS1
Entrez GeneID
4868Gene Name
NPHS1
Gene Alias
CNF, NPHN
Gene Description
nephrosis 1, congenital, Finnish type (nephrin)
Gene Ontology
HyperlinkGene Summary
Nephrin is a kidney glomerular filtration barrier protein that is an essential component of the interpodocyte-spanning slit diaphragm. Mutations in the nephrin gene are associated with congenital nephrotic syndrome (NPHS1; MIM 256300).[supplied by OMIM
Other Designations
nephrin|renal glomerulus-specific cell adhesion receptor
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Interactome
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Disease
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Publication Reference
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Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient.
Takahashi N, Kimura H, Mizuno S, Hara M, Hirayama Y, Kurosawa H, Tsutaya S, Yasujima M, Yokoi S, Mikami D, Kasuno K, Naiki H, Iwano M, Yoshida H.
Clinical and Experimental Nephrology 2012 Jun; 16(3):495.
Application：IHC, Human, Detached podocytes and capillary-attached podocytes (kidney biopsy) from patients with Gitelman syndrome.
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Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient.
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