NPHS1 monoclonal antibody, clone Y17-R
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More Files
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human NPHS1.
Immunogen
A synthetic peptide corresponding to amino acids 465-528 at internal region of the fifth Ig-like domain of human NPHS1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
EVAC purification
Isotype
IgG
Recommend Usage
ELISA (1:50000-1:100000)
Immunoprecipitation
Western Blot (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl buffer, pH 8.0 (10 mg/mL BSA, 0.05% Sodium Azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western Blot analysis of NPHS1 recombinant protein (Lane 1: 50 ng, Lane 2: 100 ng and Lane 3: 200 ng) with NPHS1 monoclonal antibody, clone Y17-R (Cat # MAB15898).Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NPHS1
Entrez GeneID
4868Protein Accession#
O60500Gene Name
NPHS1
Gene Alias
CNF, NPHN
Gene Description
nephrosis 1, congenital, Finnish type (nephrin)
Gene Ontology
HyperlinkGene Summary
Nephrin is a kidney glomerular filtration barrier protein that is an essential component of the interpodocyte-spanning slit diaphragm. Mutations in the nephrin gene are associated with congenital nephrotic syndrome (NPHS1; MIM 256300).[supplied by OMIM
Other Designations
nephrin|renal glomerulus-specific cell adhesion receptor
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Interactome
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Disease
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Publication Reference
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Early protective role of MST1 knockdown in response to experimental diabetic nephropathy.
Wu W, Zhang M, Ou S, Liu X, Xue L, Liu J, Wu Y, Li Y, Liu Q.
American Journal of Translational Research 2016 Mar; 8(3):1397.
Application:Flow Cyt, IF, Rat, Rat podocyte.
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The Dose-Dependent Organ-Specific Effects of a Dipeptidyl Peptidase-4 Inhibitor on Cardiovascular Complications in a Model of Type 2 Diabetes.
Moon JY, Woo JS, Seo JW, Lee A, Kim DJ, Kim YG, Kim SY, Lee KH, Lim SJ, Cheng XW, Lee SH, Kim W.
PLoS One 2016 Mar; 11(3):e0150745.
Application:IHC-P, Mouse, Mouse kidney.
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The renoprotective effect of shichimotsukokato on hypertension-induced renal dysfunction in spontaneously hypertensive rats.
Ma Y, Fujimoto M, Watari H, Kimura M, Shimada Y.
Nature Medicine 2016 Apr; 70(2):152.
Application:WB-Ti, Rat, Rat renal cortices.
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Early protective role of MST1 knockdown in response to experimental diabetic nephropathy.
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