CLDN1 monoclonal antibody, clone CL3698
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: RT-4 and Lane 2: U-251 MG cell lysates with CLDN1 monoclonal antibody, clone CL3698 (Cat # MAB15814).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human liver with CLDN1 monoclonal antibody, clone CL3698 (Cat # MAB15814) shows moderate membranous immunoreactivity in hepatocytes.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human CLDN1.
Immunogen
Recombinant protein corresponding to human CLDN1.
Epitope
This antibody binds to an epitope located within the peptide sequence KTTSYPTPRPYPKPA as determined by overlapping synthetic peptides.
Sequence
KTTSYPTPRPYPKPAPSSGKDYV
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: RT-4 and Lane 2: U-251 MG cell lysates with CLDN1 monoclonal antibody, clone CL3698 (Cat # MAB15814).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human liver with CLDN1 monoclonal antibody, clone CL3698 (Cat # MAB15814) shows moderate membranous immunoreactivity in hepatocytes. -
Gene Info — CLDN1
Entrez GeneID
9076Protein Accession#
O95832Gene Name
CLDN1
Gene Alias
CLD1, ILVASC, SEMP1
Gene Description
claudin 1
Gene Ontology
HyperlinkGene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq
Other Designations
senescence-associated epithelial membrane protein 1
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Interactome
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Pathway
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Disease
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