Histone macroH2A1 monoclonal antibody, clone RM248
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of acid extracts of K562 cell with Histone macroH2A1 monoclonal antibody, clone RM248 (Cat # MAB15117) at 1 ug/mL working concentration.
Immunocytochemistry
Immunocytochemistry staining of HeLa cells with Histone macroH2A1 monoclonal antibody, clone RM248 (Cat # MAB15117) (Red). Actin filaments was labeled with fluorescein phalloidin (Green).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against of human histone macroH2A1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to C-terminus of human Histone macroH2A1.
Sequence
N/A
Reactivity
Human
Specificity
This antibody reacts to the histone macroH2A1 protein, independent of post-translational modifications. No cross reactivity with other histone proteins.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG
Recommend Usage
ELISA (0.2-1 ug/mL)
Immunocytochemistry (1-2 ug/mL)
Multiplex (0.2-1 ug/mL)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of acid extracts of K562 cell with Histone macroH2A1 monoclonal antibody, clone RM248 (Cat # MAB15117) at 1 ug/mL working concentration.Immunocytochemistry
Immunocytochemistry staining of HeLa cells with Histone macroH2A1 monoclonal antibody, clone RM248 (Cat # MAB15117) (Red). Actin filaments was labeled with fluorescein phalloidin (Green).Enzyme-linked Immunoabsorbent Assay
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Gene Info — H2AFY
Entrez GeneID
9555Protein Accession#
O75367; Q9P0M6Gene Name
H2AFY
Gene Alias
H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
Gene Description
H2A histone family, member Y
Omim ID
610054Gene Ontology
HyperlinkGene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
histone macroH2A1.1|histone macroH2A1.2
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Gene Info — H2AFY2
Entrez GeneID
55506Protein Accession#
O75367; Q9P0M6Gene Name
H2AFY2
Gene Alias
macroH2A2
Gene Description
H2A histone family, member Y2
Gene Ontology
HyperlinkGene Summary
O
Other Designations
OTTHUMP00000019735|core histone macroH2A2.2
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Interactome
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Pathway
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Disease
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