CCND1 monoclonal antibody, clone DCS-6
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More Files
- More Functions
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CCND1.
Immunogen
Recombinant protein corresponding to full length human CCND1.
Host
Mouse
Theoretical MW (kDa)
33.7
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG2a
Recommend Usage
Western Blot (4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL)
Immunohistochemistry (Frozen sections) (8 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — CCND1
Entrez GeneID
595Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactome
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Pathway
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Disease
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Publication Reference
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Cyclin D1 expression is regulated by the retinoblastoma protein.
Muller H, Lukas J, Schneider A, Warthoe P, Bartek J, Eilers M, Strauss M.
PNAS 1994 Apr; 91(8):2945.
Application:WB-Ce, WB-Tr, Human, MRC-5, MCF-7, U20S, BT549, Saos-2, C33A, MTSV-1, 293, SiHa cells.
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Function of a human cyclin gene as an oncogene.
Hinds PW, Dowdy SF, Eaton EN, Arnold A, Weinberg RA.
PNAS 1994 Jan; 91(2):709.
Application:WB-Tr, Rat, BRK cells.
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Cyclin D1 expression is regulated by the retinoblastoma protein.
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