CCND1 monoclonal antibody, clone RM241
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysates with CCND1 monoclonal antibody, clone RM241 (Cat # MAB15125) at a 1: 1,000 dilution, showed a band of CCND1 (~34 kDa) expressed in HeLa cells.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with CCND1 monoclonal antibody, clone RM241 (Cat # MAB15125) at 1:1000 dilution.
Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded Human Mantle Cell Lymphoma tissue sections using CCND1 monoclonal antibody, clone RM241 (Cat# MAB15125) at a 1:1000 dilution.
Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue sections using CCND1 monoclonal antibody, clone RM241 (Cat# MAB15125) at a 1:1000 dilution.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against of human CCND1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to internal region of human CCND1.
Sequence
N/A
Reactivity
Human
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysates with CCND1 monoclonal antibody, clone RM241 (Cat # MAB15125) at a 1: 1,000 dilution, showed a band of CCND1 (~34 kDa) expressed in HeLa cells.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with CCND1 monoclonal antibody, clone RM241 (Cat # MAB15125) at 1:1000 dilution.Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded Human Mantle Cell Lymphoma tissue sections using CCND1 monoclonal antibody, clone RM241 (Cat# MAB15125) at a 1:1000 dilution.Immunohistochemistry
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue sections using CCND1 monoclonal antibody, clone RM241 (Cat# MAB15125) at a 1:1000 dilution. -
Gene Info — CCND1
Entrez GeneID
595Protein Accession#
P24385Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactome
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Pathway
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Disease
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