CCND1 monoclonal antibody, clone SPM587 (PE)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Jurkat cell (A) and MCF-7 cell (B) with CCND1 monoclonal antibody, clone SPM587 (PE) (Cat # MAB13021) (red). Black: cells alone. Green: isotype control.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human CCND1.
Immunogen
Recombinant protein corresponding to full length human CCND1.
Host
Mouse
Reactivity
Human
Form
Liquid
Conjugation
PE
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (5 uL per test per one million cells in 0.1 mL)
Immunofluorescence (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
Flow cytometric analysis of Jurkat cell (A) and MCF-7 cell (B) with CCND1 monoclonal antibody, clone SPM587 (PE) (Cat # MAB13021) (red). Black: cells alone. Green: isotype control. -
Gene Info — CCND1
Entrez GeneID
595Protein Accession#
P24385Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactome
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Pathway
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Disease
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