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Immunohistochemistry (Frozen sections)

Entrez GeneID

Gene Name

TNNT1

Gene Alias

ANM, FLJ98147, MGC104241, STNT, TNT, TNTS

Gene Description

troponin T type 1 (skeletal, slow)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

slow skeletal muscle troponin T|troponin T1, skeletal, slow|troponin-T1, skeletal, slow

Entrez GeneID

Gene Name

TNNT2

Gene Alias

CMH2, CMPD2, MGC3889, RCM3, TnTC, cTnT

Gene Description

troponin T type 2 (cardiac)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq

Other Designations

OTTHUMP00000033864|OTTHUMP00000033867|cardiomyopathy, dilated 1D (autosomal dominant)|cardiomyopathy, hypertrophic 2|troponin T type 2, cardiac|troponin T, cardiac muscle|troponin T2, cardiac

Entrez GeneID

Gene Name

TNNT3

Gene Alias

AMCD2B, DA2B, DKFZp779M2348, FSSV

Gene Description

troponin T type 3 (skeletal, fast)

Omim ID

Gene Ontology

Gene Summary

O

Other Designations

OTTHUMP00000014433|OTTHUMP00000014434|OTTHUMP00000014435|troponin T3, skeletal, fast|troponin-T3, skeletal, fast