Products

Western Blot (Cell lysate)

Western blot analysis using LIMS1 monoclonal antobody, clone 5G7 (Cat # MAB10297) against A-549 (1), Jurkat (2), and HeLa (3) cell lysate.

Western Blot (Recombinant protein)

Western blot analysis using LIMS1 monoclonal antobody, clone 5G7 (Cat # MAB10297) against recombinant human LIMS1 protein.

Immunofluorescence

Immunofluorescence analysis of HepG2 cells using LIMS1 monoclonal antobody, clone 5G7 (Cat # MAB10297) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Flow cytometric analysis of HeLa cells using LIMS1 monoclonal antobody, clone 5G7 (Cat # MAB10297) (blue) and negative control (red).

Entrez GeneID

3987

Gene Name

LIMS1

Gene Alias

PINCH, PINCH1

Gene Description

LIM and senescent cell antigen-like domains 1

Omim ID

602567

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. [provided by RefSeq

Other Designations

OTTHUMP00000161608