UGT1A9 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Western Blot (Tissue lysate)
UGT1A9 MaxPab polyclonal antibody. Western Blot analysis of UGT1A9 expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of UGT1A9 expression in transfected 293T cell line (H00054600-T01) by UGT1A9 MaxPab polyclonal antibody.
Lane 1: UGT1A9 transfected lysate(58.3 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to UGT1A9 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human UGT1A9 protein.
Immunogen
UGT1A9 (NP_066307.1, 1 a.a. ~ 530 a.a) full-length human protein.
Sequence
MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (78); Rat (79)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
UGT1A9 MaxPab polyclonal antibody. Western Blot analysis of UGT1A9 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of UGT1A9 expression in transfected 293T cell line (H00054600-T01) by UGT1A9 MaxPab polyclonal antibody.
Lane 1: UGT1A9 transfected lysate(58.3 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to UGT1A9 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml] -
Gene Info — UGT1A9
Entrez GeneID
54600GeneBank Accession#
NM_021027.2Protein Accession#
NP_066307.1Gene Name
UGT1A9
Gene Alias
HLUGP4, LUGP4, UDPGT, UGT1AI
Gene Description
UDP glucuronosyltransferase 1 family, polypeptide A9
Omim ID
606434Gene Ontology
HyperlinkGene Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq
Other Designations
UDP glycosyltransferase 1 family, polypeptide A9|UDP-glucuronosyltransferase 1A9
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Interactome
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Pathway
- Androgen and estrogen metabolism
- Ascorbate and aldarate metabolism
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Metabolic pathways
- Metabolism of xenobiotics by cytochrome P450
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Retinol metabolism
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Disease
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Publication Reference
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Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers.
Wang H, Bian T, Jin T, Chen Y, Lin A, Chen C.
Pharmacogenomics 2014 Apr; 15(6):785.
Application：WB-Ti, Human, Liver.
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Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease.
Hardwick RN, Ferreira DW, More VR, Lake AD, Lu Z, Manautou JE, Slitt AL, Cherrington NJ.
Drug Metabolism and Disposition 2012 Dec; 41(3):554.
Application：WB, Human, Patients with nonalcoholic fatty liver disease.
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Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers.
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