IRAK4 monoclonal antibody (M03), clone 1D11
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant IRAK4.
Immunogen
IRAK4 (AAH13316, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDK
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (83); Rat (83)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (39.93 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged IRAK4 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — IRAK4
Entrez GeneID
51135GeneBank Accession#
BC013316Protein Accession#
AAH13316Gene Name
IRAK4
Gene Alias
IPD1, NY-REN-64, REN64
Gene Description
interleukin-1 receptor-associated kinase 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq
Other Designations
IRAK-4 mutated form 1|interleukin-1 receptor associated kinase 4
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Interactome
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Pathway
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Disease
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