NFASC (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human NFASC partial ORF ( NP_001005388, 661 a.a. - 758 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.52
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NFASC
Entrez GeneID
23114GeneBank Accession#
NM_001005388Protein Accession#
NP_001005388Gene Name
NFASC
Gene Alias
DKFZp686P2250, FLJ46866, KIAA0756, NF, NRCAML
Gene Description
neurofascin homolog (chicken)
Omim ID
609145Gene Ontology
HyperlinkGene Summary
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined
Other Designations
OTTHUMP00000065305|OTTHUMP00000065306|OTTHUMP00000065307|OTTHUMP00000065308|OTTHUMP00000065313|OTTHUMP00000065315|OTTHUMP00000065321|OTTHUMP00000065322|OTTHUMP00000065324|neurofascin
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Interactome
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Pathway
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Disease
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