IL24 monoclonal antibody (M01), clone 4B6
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More Files
- More Functions
Immunoprecipitation
Immunoprecipitation of IL24 transfected lysate using anti-IL24 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IL24 MaxPab rabbit polyclonal antibody.
Western Blot detection against Immunogen (37.73 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant IL24.
Immunogen
IL24 (AAH09681, 58 a.a. ~ 167 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (66); Rat (63)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.73 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunoprecipitation
Immunoprecipitation of IL24 transfected lysate using anti-IL24 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IL24 MaxPab rabbit polyclonal antibody.ELISA
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Gene Info — IL24
Entrez GeneID
11009GeneBank Accession#
BC009681Protein Accession#
AAH09681Gene Name
IL24
Gene Alias
C49A, FISP, IL-24, IL10B, MDA7, Mob-5, ST16, mda-7
Gene Description
interleukin 24
Omim ID
604136Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
IL-24 splice variant delE3|IL-24 splice variant delE5|OTTHUMP00000034620|melanoma differentiation association protein 7|suppression of tumorigenicity 16 (melanoma differentiation)
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Interactome
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Pathway
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Disease
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