Products

Western Blot (Transfected lysate)

Western Blot analysis of CREB3 expression in transfected 293T cell line by CREB3 monoclonal antibody (M01), clone 3H5.

Lane 1: CREB3 transfected lysate(41.4 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunoperoxidase of monoclonal antibody to CREB3 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]

Sandwich ELISA (Recombinant protein)

Detection limit for recombinant GST tagged CREB3 is approximately 0.1ng/ml as a capture antibody.

ELISA

RNAi Knockdown (Antibody validated)

Western blot analysis of CREB3 over-expressed 293 cell line, cotransfected with CREB3 Validated Chimera RNAi ( Cat # H00010488-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CREB3 monoclonal antibody (M01), clone 3H5 (Cat # H00010488-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Entrez GeneID

10488

GeneBank Accession#

NM_006368

Protein Accession#

NP_006359

Gene Name

CREB3

Gene Alias

LUMAN, LZIP, MGC15333, MGC19782

Gene Description

cAMP responsive element binding protein 3

Omim ID

606443

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq

Other Designations

OTTHUMP00000021348|basic leucine zipper protein|cyclic AMP response element (CRE)-binding protein/activating transcription factor 1|transcription factor LZIP-alpha