Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

MAP2K4

Gene Alias

JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1

Gene Description

mitogen-activated protein kinase kinase 4

Omim ID

Gene Ontology

Gene Summary

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq

Other Designations

JNK activating kinase 1|JNK-activated kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4