PSMD10 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PSMD10 DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — PSMD10
Entrez GeneID
5716GeneBank Accession#
NM_002814.2Protein Accession#
NP_002805.1Gene Name
PSMD10
Gene Alias
dJ889N15.2, p28
Gene Description
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Omim ID
603480Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. [provided by RefSeq
Other Designations
26S proteasome non-ATPase regulatory subunit 10|26S proteasome regulatory subunit p28|OTTHUMP00000023827|OTTHUMP00000023828|ankyrin repeat protein|gankyrin|hepatocellular carcinoma-associated protein p28-II|proteasome 26S non-ATPase subunit 10
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