MAG (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human MAG full-length ORF ( NP_002352.1, 1 a.a. - 626 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MIFLTALPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPPVLFSSDFRISGAPEKYESERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
95.5
Interspecies Antigen Sequence
Mouse (94); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MAG
Entrez GeneID
4099GeneBank Accession#
NM_002361.2Protein Accession#
NP_002352.1Gene Name
MAG
Gene Alias
GMA, S-MAG, SIGLEC-4A, SIGLEC4A
Gene Description
myelin associated glycoprotein
Omim ID
159460Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
myelin-associated glycoprotein|sialic acid-binding immunoglobulin-like lectin 4A
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Interactome
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Pathway
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Disease
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Publication Reference
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Pathophysiology of hypoperfusion of the precuneus in early Alzheimer's disease.
Miners JS, Palmer JC, Love S.
Brain Pathology 2016 Jul; 26(4):533.
Application：ELISA, Human, Brain.
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Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins.
Barker R, Wellington D, Esiri MM, Love S.
Journal of Cerebral Blood Flow and Metabolism 2013 Jul; 33(7):1050.
Application：ELISA, As a standard of ELISA.
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Neural cell adhesion molecule - Description of a CSF ELISA method and evidence of reduced levels in selected neurological disorders.
Gnanapavan S, Grant D, Illes-Toth E, Lakdawala N, Keir G, Giovannoni G.
Journal of Neuroimmunology 2010 Aug; 225(1-2):118.
Application：Func, Capture antibody.
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Pathophysiology of hypoperfusion of the precuneus in early Alzheimer's disease.
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